The Ricky Gervais Show Description: Two famous comedians bully a guy named Karl Pilkington. I don’t know where you can find the original podcasts for free anymore, but the concept have evolved to the animated series The Ricky Gervais Show and An Idiot Abroad.
Webcomics Weekly Description: Four famous webcartoonists talk about webcomics. Informative and surprisingly funny!
This American Life This podcast is simply the best and most interesting radio program in the known universe! This American Life is a weekly public radio show broadcast on more than 500 stations to about 1.8 million listeners. There’s a theme to each episode, and a variety of stories on that theme. It’s mostly true stories of everyday people, though not always.
BULLSEYE (the podcast formerly known as ”The Sound of Young America”) Description: A show about things that are awesome. The program features host Jesse Thorn, who refers to himself as “America’s Radio Sweetheart,” interviewing personalities in arts and culture, with a special focus on comedy.
Freakonomics Radio Description: In their books Freakonomics and SuperFreakonomics, Steven D. Levitt and Stephen J. Dubner use the tools of economics to explore real-world behavior. As boring as that may sound, what they really do is tell stories — about cheating schoolteachers, self-dealing real-estate agents, and crack-selling mama’s boys.
WTF WITH MARC MARON is a twice-weekly podcast hosted by stand up comedian Marc Maron. The program primarily consists of interviews with comedians and comedy writers. Funny, but also serious and sometimes dark.
TEDTalks Audio Podcasts Podcast versions of TEDTalks. Some of my favorite lectures: Barry Schwartz, Bjorn Lomborg, Dan Ariely, Dan Gilbert, Dan Pink, Ken Robinson, Malcolm Gladwell, Richard Dawkins, Sam Harris, Steven Levitt, and Steven Pinker.
Skeptoid Description: Skeptoid is a weekly science podcast dedicated to furthering knowledge by blasting away the widespread pseudosciences that infect popular culture, and replacing them with way cooler reality. Each weekly episode focuses on a single phenomenon — an urban legend, a paranormal claim, alternative therapy, or something just plain stupid.
I also like these four Swedish podcasts.
If you don’t understand Swedish you can stop reading now 
The Johan Wanloo Show Beskrivning: Sveriges bästa serietecknare genom alla tider (i mitt tycke i alla fall) rockar loss med en podcast som är lika galen som hans serier!
P3 Dokumentär Beskrivning: P3 Dokumentär är programmet som blickar bakåt, gräver i arkiven och pratar med dom som var med när det hände, där det hände. Min favoritepisod är nog “tattarkravallerna” i Jönköping 1948. Jag är från Jönköping och kände inte ens till incidenten.
Skeptikerpodden Ifrågasätter pseudovetenskap, vidskepelse och övernaturliga fenomen. Allt under ledning av den alltid lika trevliga John Houdi och en redaktion med kunskaper inom bland annat kritiskt tänkande, vetenskap, trolleri, medicin, psykologi med mera.
TSKNAS (Till Slut Kommer Någon Att Skratta) Några av Sveriges bästa (och ibland sämsta) komiker sitter och snackar skit… Varierande kvalitet, men när det är som bäst så är det riktigt underhållande.
