The Ricky Gervais Show Description: Two famous comedians bully a guy named Karl Pilkington. I don’t know where you can find the original podcasts for free anymore, but the concept have evolved to the animated series The Ricky Gervais Show and An Idiot Abroad.
Webcomics Weekly Description: Four famous webcartoonists talk about webcomics. Informative and surprisingly funny!
The Sound of Young America Description: A show about things that are awesome. The program features host Jesse Thorn, who refers to himself as “America’s Radio Sweetheart,” interviewing personalities in arts and culture, with a special focus on comedy.
Freakonomics Radio Description: In their books Freakonomics and SuperFreakonomics, Steven D. Levitt and Stephen J. Dubner use the tools of economics to explore real-world behavior. As boring as that may sound, what they really do is tell stories — about cheating schoolteachers, self-dealing real-estate agents, and crack-selling mama’s boys.
TEDTalks Audio Podcasts Podcast versions of TEDTalks. Some of my favorite lectures: Barry Schwartz, Bjorn Lomborg, Dan Ariely, Dan Gilbert, Dan Pink, Ken Robinson, Malcolm Gladwell, Richard Dawkins, Sam Harris, Steven Levitt, and Steven Pinker.
Skeptoid Description: Skeptoid is a weekly science podcast dedicated to furthering knowledge by blasting away the widespread pseudosciences that infect popular culture, and replacing them with way cooler reality. Each weekly episode focuses on a single phenomenon — an urban legend, a paranormal claim, alternative therapy, or something just plain stupid.
Escape from Illustration Island Podcast Description: Weekly conversations with Illustrators, Art Directors, Art Reps, and other creative professionals about the Illustration industry.
I also like these three Swedish podcasts.
If you don’t understand Swedish you can stop reading now 
The Johan Wanloo Show Beskrivning: Sveriges bästa serietecknare genom alla tider (i mitt tycke i alla fall) rockar loss med en podcast som är lika galen som hans serier!
P3 Dokumentär Beskrivning: P3 Dokumentär är programmet som blickar bakåt, gräver i arkiven och pratar med dom som var med när det hände, där det hände. Min favoritepisod är nog “tattarkravallerna” i Jönköping 1948. Jag är från Jönköping och kände inte ens till incidenten.
Skeptikerpodden Ifrågasätter pseudovetenskap, vidskepelse och övernaturliga fenomen. Allt under ledning av den alltid lika trevliga John Houdi och en redaktion med kunskaper inom bland annat kritiskt tänkande, vetenskap, trolleri, medicin, psykologi med mera.
